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Table 2 Quality characteristics of modelling studies

From: Health economic evaluations comparing insulin glargine with NPH insulin in patients with type 1 diabetes: a systematic review

Author/Study
(year of publication)
Brändle et al. [25] Cameron et al. [21] McEwan et al. [23] Grima et al. [22] Warren et al. [24] Warren et al. [20]
Research question clearly defined () ()
Perspective named () ()
Considered health effects HbA1c,
hypoglycaemia,
fear of hypogl.
HbA1c,
hypoglycaemia,
fear of hypogl.1
HbA1c,
hypoglycaemia,
fear of hypogl.
HbA1c HbA1c1,
hypoglycaemia,
fear of hypogl.
HbA1c1,
hypoglycaemia,
fear of hypogl.
Source of efficacy data Meta-analysis2,
Meta-regression
Meta-analysis Meta-analysis2 RCT RCT Meta-analysis, RCT
Determination of efficacy via information synthesis - - - -
Complications of diabetes considered 1 1
All relevant costs considered () () () () ()
Discounting (rate) C (3,5%),
E (3,5%)
C (5%),
E (5%)
C (3,5%),
E (3,5%)
C (5%),
E (5%)
C (3,5%),
E (3,5%)
C (3,5%),
E (3,5%)
Incremental analysis
Sensitivity analysis
Results of sensitivity analysis described ()
Results presented per capita
Research question answered
Strength and weakness of studies discussed - - () ()
  1. Legends: C = cost, E = effectiveness, HbA1c = haemoglobin A1c, RCT = randomised controlled trial. 1Parameter included in sensitivity analysis only, 2unpublished material