Figure 2

Intrinsic value estimate for intervention on the MCDA Value Matrix scale and value contribution of each component. *For an intervention to achieve close to 100% on this scale, it would have to cure a severe endemic disease, demonstrate a major improvement in safety, efficacy and PRO compared to limited existing approaches, and result in major healthcare savings. Conversely, an intervention that scores low would be for a rare disease that is not severe, with minimal improvement in efficacy over existing alternatives, with major safety and PRO issues and resulting in major increases in healthcare spending.