Lifetime health effects and medical costs of integrated stroke services - a non-randomized controlled cluster-trial based life table approach

Table 2 Estimates for the disability-stratified stroke-simulation model

Parameter		Unit	Data source	Value*
Epidemiological measure:
Age distribution incident strokes		Rate	Jager [34]	8.46
All cause mortality		Rate	Statistics Netherlands [35]	33.0
Stroke mortality		Rate		1.9
Cardiovascular mortality		Rate		8.4
Death from stroke		Ratio	Herman [36]/Bamford [37]	0.21
Recurrent after mRS 0-3		Relative risk	Hoogen [38]/Dennis [39]/Dutch TIA Trial [40]
first year	< 75 years			0.09
	> 75 years
subsequent years				0.05
Late death from mRS 4-5		Ratio	Howard [41, 42]	0.15
Death from cardiac disease	after mRS 0-3 stroke	Relative risk	Dutch TIA Trial[40]/Howard [41, 42]	0.038
	after mRS 4-5 stroke	Relative risk	Howard [41, 42]	0.06
Utility weights for stroke disability categories		-	EDISSE data [14]	0-1
Disability after stroke (first-ever and recurrent)		mRS		1-5
Hazard ratios:
Excess cardiovascular death	mRS 0-1:mRS 2-3	Hazard ratio	LiLAC study Group [18]	1.25^†
	mRS 4:mRS 5	Hazard ratio		1.25
Recurrent stroke	mRS 0-1:mRS 2-3	Hazard ratio		1.34
	mRS 4:mRS 5	Hazard ratio		1.34

Note: * number per 1,000 or probability for men aged 70-75. ^† The ratio reported in the Lilac study concerned all vascular events. We assume that the hazard ratio is equal for both cardiovascular event and other vascular events.

ISSN: 1478-7547