Parameters | Base case | Ranges | References |
---|---|---|---|
Screening characteristics | Â | Â | Â |
Screening interval | 3 years in ages 25–49 years and 5 years in ages 50–64 years |  | NHS cervical screening programme 22 |
Coverage rates of target groups by age (2003) | Â | Â | Â |
25–29 | 74.0% |  | NHS cervical screening programme 22 |
30–34 | 81.0% |  |  |
35–39 | 83.7% |  |  |
40–44 | 84.0% |  |  |
45–49 | 83.8% |  |  |
50–54 | 83.2% |  |  |
55–59 | 81.4% |  |  |
60–64 | 77.3% |  |  |
Inadequate pap smear results | 10% | 5% – 20% |  |
Pap Sensitivity for CIN 1/2 Pap sensitivity for CIN 1/2 (LBC) | 61% | 51% – 80% | Nanda et al23and Karnon et al25 |
Pap Sensitivity for CIN 3 Pap Sensitivity for CIN 3 (LBC) | 65% | 65% – 90% | Nanda et al23 and Karnon et al25 |
Pap Specificity for no CIN Pap Specificity for no CIN (LBC) | 95.7% | 90% – 99% | Nanda et al25 and Kulasingam et al24 |
Colposcopy/Biopsy Sensitivity | 90% | 88% – 100% | Mitchell et al27 |
Colposcopy/Biopsy Specificity | 100% | 65% – 100% | Kulasingam et al24 and Karnon et al25 |
Vaccine characteristics | Â | Â | Â |
Vaccine efficacy for all 6, 11, 16, 18 HPV types | 98% | 85% – 100% | Villa et al5 and Future II 6 |
Duration of efficacy | Lifetime | From 10 years to lifetime | Olsson et al 28 and Villa et al42 |
Vaccine coverage | 85% | 50%–90% | Trotter et al31 and Bramley et al32 |
Booster coverage | Â | 50% | Trotter et al31 |
Costs | Â | Â | Â |
Pap smear | £23.7 | £18 – £30 | Brown et al 26 Curtis et al38 |
Colposcopy (with or without biopsy) | £141.69 | £113 – £170 |  |
Knife cone biopsy of cervix uteri | £290.64 | £232 – £349 |  |
CIN 1, CIN 2, CIN 3 | £313.14 | £250 – £376 |  |
FIGO I | £12,142 | £9,714 – £14,570 | Curtis et al38 and Wolstenholme et al37 |
FIGO II | £22,061 | £17,649 – £26,473 |  |
FIGO III | £21,785 | £17,428 – £26,142 |  |
FIGO IV | £23,402 | £18,722 – £28,082 |  |
Genital warts | £215.73 | £172 – £259 | Brown et al26 and Curtis et al38 |
Vaccine cost/dose | £75 | £70 – £80 |  |
Administration cost/dose | £ 3.4 | £0 – £12 | Trotter et al31 |
Booster cost/dose |  | £75 |  |
Administration cost for booster |  | £10 | Curtis et al38 |
Discount rates | Â | Â | Â |
Costs | 3.5% | 0 – 5% |  |
Benefits | 3.5% | 0 – 5% |  |