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Table 2 Screening, vaccine and cost parameters

From: Adding a quadrivalent human papillomavirus vaccine to the UK cervical cancer screening programme: A cost-effectiveness analysis

Parameters Base case Ranges References
Screening characteristics    
Screening interval 3 years in ages 25–49 years and 5 years in ages 50–64 years   NHS cervical screening programme 22
Coverage rates of target groups by age (2003)    
25–29 74.0%   NHS cervical screening programme 22
30–34 81.0%   
35–39 83.7%   
40–44 84.0%   
45–49 83.8%   
50–54 83.2%   
55–59 81.4%   
60–64 77.3%   
Inadequate pap smear results 10% 5% – 20%  
Pap Sensitivity for CIN 1/2 Pap sensitivity for CIN 1/2 (LBC) 61% 51% – 80% Nanda et al23and Karnon et al25
Pap Sensitivity for CIN 3 Pap Sensitivity for CIN 3 (LBC) 65% 65% – 90% Nanda et al23 and Karnon et al25
Pap Specificity for no CIN Pap Specificity for no CIN (LBC) 95.7% 90% – 99% Nanda et al25 and Kulasingam et al24
Colposcopy/Biopsy Sensitivity 90% 88% – 100% Mitchell et al27
Colposcopy/Biopsy Specificity 100% 65% – 100% Kulasingam et al24 and Karnon et al25
Vaccine characteristics    
Vaccine efficacy for all 6, 11, 16, 18 HPV types 98% 85% – 100% Villa et al5 and Future II 6
Duration of efficacy Lifetime From 10 years to lifetime Olsson et al 28 and Villa et al42
Vaccine coverage 85% 50%–90% Trotter et al31 and Bramley et al32
Booster coverage   50% Trotter et al31
Costs    
Pap smear £23.7 £18 – £30 Brown et al 26
Curtis et al38
Colposcopy (with or without biopsy) £141.69 £113 – £170  
Knife cone biopsy of cervix uteri £290.64 £232 – £349  
CIN 1, CIN 2, CIN 3 £313.14 £250 – £376  
FIGO I £12,142 £9,714 – £14,570 Curtis et al38 and Wolstenholme et al37
FIGO II £22,061 £17,649 – £26,473  
FIGO III £21,785 £17,428 – £26,142  
FIGO IV £23,402 £18,722 – £28,082  
Genital warts £215.73 £172 – £259 Brown et al26 and Curtis et al38
Vaccine cost/dose £75 £70 – £80  
Administration cost/dose £ 3.4 £0 – £12 Trotter et al31
Booster cost/dose   £75  
Administration cost for booster   £10 Curtis et al38
Discount rates    
Costs 3.5% 0 – 5%  
Benefits 3.5% 0 – 5%