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Table 2 Screening, vaccine and cost parameters

From: Adding a quadrivalent human papillomavirus vaccine to the UK cervical cancer screening programme: A cost-effectiveness analysis

Parameters

Base case

Ranges

References

Screening characteristics

   

Screening interval

3 years in ages 25–49 years and 5 years in ages 50–64 years

 

NHS cervical screening programme 22

Coverage rates of target groups by age (2003)

   

25–29

74.0%

 

NHS cervical screening programme 22

30–34

81.0%

  

35–39

83.7%

  

40–44

84.0%

  

45–49

83.8%

  

50–54

83.2%

  

55–59

81.4%

  

60–64

77.3%

  

Inadequate pap smear results

10%

5% – 20%

 

Pap Sensitivity for CIN 1/2 Pap sensitivity for CIN 1/2 (LBC)

61%

51% – 80%

Nanda et al23and Karnon et al25

Pap Sensitivity for CIN 3 Pap Sensitivity for CIN 3 (LBC)

65%

65% – 90%

Nanda et al23 and Karnon et al25

Pap Specificity for no CIN Pap Specificity for no CIN (LBC)

95.7%

90% – 99%

Nanda et al25 and Kulasingam et al24

Colposcopy/Biopsy Sensitivity

90%

88% – 100%

Mitchell et al27

Colposcopy/Biopsy Specificity

100%

65% – 100%

Kulasingam et al24 and Karnon et al25

Vaccine characteristics

   

Vaccine efficacy for all 6, 11, 16, 18 HPV types

98%

85% – 100%

Villa et al5 and Future II 6

Duration of efficacy

Lifetime

From 10 years to lifetime

Olsson et al 28 and Villa et al42

Vaccine coverage

85%

50%–90%

Trotter et al31 and Bramley et al32

Booster coverage

 

50%

Trotter et al31

Costs

   

Pap smear

£23.7

£18 – £30

Brown et al 26

Curtis et al38

Colposcopy (with or without biopsy)

£141.69

£113 – £170

 

Knife cone biopsy of cervix uteri

£290.64

£232 – £349

 

CIN 1, CIN 2, CIN 3

£313.14

£250 – £376

 

FIGO I

£12,142

£9,714 – £14,570

Curtis et al38 and Wolstenholme et al37

FIGO II

£22,061

£17,649 – £26,473

 

FIGO III

£21,785

£17,428 – £26,142

 

FIGO IV

£23,402

£18,722 – £28,082

 

Genital warts

£215.73

£172 – £259

Brown et al26 and Curtis et al38

Vaccine cost/dose

£75

£70 – £80

 

Administration cost/dose

£ 3.4

£0 – £12

Trotter et al31

Booster cost/dose

 

£75

 

Administration cost for booster

 

£10

Curtis et al38

Discount rates

   

Costs

3.5%

0 – 5%

 

Benefits

3.5%

0 – 5%

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