Do coxibs reduce prescription of gastroprotective agents? Results of a record linkage study

Table 2 Odds ratio (95% CI) of GPA prescription (proton pump inhibitors, H₂ blockers and misoprostol) – occurring the same day or within 30 days – for coxib vs. oral non selective NSAIDs adult users

			Adjusted ^# odds ratio (95% CI) of GPA prescription (coxib vs. non selective NSAIDs users)
Patients' profile	N.	%	Co-prescription of GPAs (same day)	Prescription of GPAs within 30 days
No NSAIDs and/or GPAs in the previous 4 years	30,658	42.8	1.1 (0.9–1.3)	1.7 (1.3–2.1) °
No NSAIDs in the previous 4 years	36,077	50.4	1.2 (1.0–1.4) *	1.6 (1.3–1.8) °
Acute patients †	52,608	73.5	1.3 (1.0–1.7)	1.7 (1.3–2.3) °
Chronic patients ‡	18,993	26.5	1.2 (1.0–1.5) *	1.7 (1.3–2.3) °
All patients	71,601	100	1.1 (1.0–1.2)	2.0 (1.8–2.2) °

† Individuals who had been prescribed less than 60 DDD of NSAIDs (either selective or non selective) during 2001
‡ Individuals who had been prescribed at least 60 DDD of NSAIDs (either selective or non selective) during 2001
# Adjusted for age, sex, DDD of coxib and NSAID received during 2001, and (not for incident patients) DDD of GPAs and NSAIDs received during the previous 4 years
* p < 0.05
° p < 0.001

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