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Table 5 Sensitivity analyses

From: Financing and cost-effectiveness analysis of public-private partnerships: provision of tuberculosis treatment in South Africa

 

PWP model

PNP model

Purely public model

 

Site 1

Site 2

Site 3

Site 4

Site 5

Site6

Alternative estimates of provider costs (staff time)

      

• % divergence from base-case provider cost estimate

-15%

-13%

-8%

-8%

-24%

-28%

• % divergence from base-case provider cost-effectiveness estimate

-15%

-13%

-8%

-8%

-24%

-28%

Lower limit patient cost

      

• % divergence from base-case patient cost estimate

N.A.*

N.A.

-5%

-5%

-5%

-5%

• % divergence from base-case patient cost-effectiveness estimate

N.A.

N.A.

-4%

-3%

-1%

-1%

Upper limit patient cost

      

• % divergence from base-case patient cost estimate

N.A.

N.A.

+5%

+5%

+5%

+5%

• % divergence from base-case patient cost-effectiveness estimate

N.A.

N.A

+3%

+0.2%

+0.6%

+2%

0% discount rate

      

• % divergence from base-case provider cost estimate

-3%

-3%

-3%

-3%

-3%

-3%

• % divergence from provider cost-effectiveness estimate

-2%

-0.6%

-0.5%

-2%

-1%

-0.5%

6% discount rate

      

• % divergence from base-case provider cost estimate

+3%

+3%

+3%

+3%

+3%

+3%

• % divergence from provider cost-effectiveness estimate

+3%

+2%

+2%

+3%

+2%

+2%

Effectiveness adjusted by the death rate**

      

• % divergence from base-case treatment success rate

-12%

-11%

-4%

-8%

-1%

-2%

• % divergence from base-case societal cost-effectiveness estimate (treatment success rate)

-12%

-11%

-4%

-8%

-1.6%

-2.5%

• % divergence from base-case cure rate

-12%

-11%

-4%

-8%

-1%

-2%

• % divergence from base-case societal cost-effectiveness estimate (cure rate)

-12%

-11%

-4%

-8%

-1%

-2%

Multivariate analysis (estimates of provider cost and effectiveness adjusted by the death rate are varied at the same time)

      

• % divergence from base-case provider cost estimate

-15%

-13%

-8%

-8%

-24%

-28%

• % divergence from base-case cure rate

-12%

-11%

-4%

-8%

-1%

-2%

• % divergence from base-case societal cost-effectiveness estimate

-25%

-23%

-11%

-15%

-25%

-30%

  1. * N.A. = not applicable.
  2. **Effectiveness was re-calculated by adjusting the total number of patients in the cohort by the total number of deaths in the same cohort. In this case, the treatment success rate = [number of successfully treated patients/(total number of patients – number of patients who died during treatment)] * 100. For example, in site 1, the treatment success rate adjusted by the death rate = [83/(95 - 11)] * 100 = 99%.