The cost-effectiveness of neonatal screening for Cystic Fibrosis: an analysis of alternative scenarios using a decision model

Table 3 Model parameters, data sources and values used in the model.

Utility values of symptom states
Variable	Base case value	Range used in sensitivity analysis
Asymptomatic – late^a	0.95	0.90
Asymptomatic – early^b	0.95	0.90
Symptoms (FEV1 – 60%, range 40%–80%) [17,41]	0.75	0.65 – 0.90
Severe irreversible symptoms (FEV1 – 30%, range 20–40%) [17,41]	0.68	0.58 – 0.78

^a utility value to reflect "taking regular medication or staying on a prescribed health diet for health reasons" derived from community surveys.
^b arbitrary utility weight to reflect the probable repeated visits to GP with undiagnosed CF

ISSN: 1478-7547