Probabilities | Â | Â |
---|---|---|
Variable | Base case value | Range used in sensitivity analysis |
Incidence of cystic fibrosis [2] | 0.0004 | 0.00067 – 0.00029 |
% diagnosed at birth (MI & family history) [39] | 0.15 | 0.10 – 0.40 |
IRT test sensitivity [40] | 0.9 | 0.99 |
IRT test specificity [40] | 0.995 | 0.999 |
DNA test: % of mutations detected [40] | 0.88 | 0.85 – 0.95 |
DNA test sensitivity [40] | 0.9856 | 0.9975 |
DNA test specificitya | 1.0 | Â |
Increased annual transition probability of remaining without symptoms (in early-diagnosed cases)b | 10% | 10 – 40% |