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Table 4 Comparisons of Drug Acquisition Costs of 5-Year NNT Among Antihypertensive Drug Classes

From: A cost-minimization analysis of diuretic-based antihypertensive therapy reducing cardiovascular events in older adults with isolated systolic hypertension

Drug Class

Commonly Prescribed

5-year Cost Per Patient

5-Year NNT

Total Cost

Incremental Cost

Cost Ratio

SHEP-based drug therapy

 

$456

15

$6,843

$0 (base)

1 (base)

Beta-Blocker

Atenolol

     
 

   25 mg daily

$1,255

15

$18,825

$11,982

2.75

 

   50 mg daily

$1,245

15

$18,675

$11,832

2.73

 

   100 mg daily

$1,792

15

$26,880

$20,037

3.93

ACE inhibitor

Enalapril

     
 

   5 mg daily

$2,031

15

$30,465

$23,622

4.45

 

   10 mg daily

$2,132

15

$31,980

$25,137

4.67

 

   20 mg daily

$3,034

15

$45,510

$38,667

6.65

Alpha-Blocker

Terazosin

     
 

   2 mg daily

$2,984

15

$44,760

$37,917

6.54

 

   5 mg daily

$2,984

15

$44,760

$37,917

6.54

 

   10 mg daily

$2,984

15

$44,760

$37,917

6.54

Calcium channel blocker

Nifedipine

     
 

   30 mg daily

$881

15

$13,215

$6,372

1.93

 

   60 mg daily

$1,762

15

$26,430

$19,587

3.86

 

   90 mg daily

$2,644

15

$39,660

$32,817

5.8