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Table 3 Health benefits and costs for metformin and the combination of metformin with nateglinide

From: Health and economic impact of combining metformin with nateglinide to achieve glycemic control: Comparison of the lifetime costs of complications in the U.K

  Metformin Combination Difference
Cumulative cost (mean per patient)    
   Complications £3,548 £3,084 £-464
   Total £5,093 £7,159 £2,066
Survival (mean, years)    
   Life years (discounted) 13.5 (11.7) 13.9 (12.1) 0.39 (0.32)
   Quality Adjusted (discounted) 12.2 (10.7) 12.6 (11.0) 0.46 (0.37)
Cost-effectiveness    
   Cost per LYG (discounted LYG)    £5,403 (6,772)
   Cost per QALY (discounted QALY)    £4,500 (5,609)
  1. LYG = Life Year Gained QALY = Quality Adjusted Life Year