Table 1 Summary of systematic review result
From: Comparing the cost effectiveness of harm reduction strategies: a case study of the Ukraine
| Study | Comparator | Intervention Evaluated | Form of economic analyses | Perspective taken | Model used | Time horizon | Outcome measure |
|---|---|---|---|---|---|---|---|
| Jones et al. [11]† | Cost utility (N = 12) Cost benefit (N = 1) | Behavioural models using simplified Bernoulli process (N = 4) simulated the transmission (N = 2) the theory of needle circulation originally developed by Kaplan and O’Keefe (N = 4) | HIV incidence (N = 11) HCV incidence (N = 1) HIV and HCV incidence (N = 1) | ||||
| Connock et al. [12]† | Cost–utility (N = 5) | Societal perspective (N = 5) healthcare system (N = 6) | Markov (N = 3) Dynamic (N = 3) Monte Carlo (N = 1) | QALY (N = 6) | |||
| Belani and Muennig [13] | no NSP | NSP | Cost utility | Societal | Decision model | 1 year | Infection averted & QALYs |
| Wammes et al. [14] | OST | OST (coverage 5% to 40%) | Cost effectiveness/cost analysis | Societal | Mathematical transmission model | 20 year | Infection averted |
| Guinness et al. [15] | non intervention | OST | Cost utility | Provider | Mathematical model | 3 year | Infection averted & DALYs |
| Tran, Mills, et al. [16] | non OST | OST | Cost utility | Health service provider | Real cohort data | 9 month | QALYs |
| Tran, Nguyen, et al. [17] | non OST | OST | cost utility | Vietnam health care system | Decision analytical model | 1 year | Infection averted & QALYs |
| Tran, Ohinmaa, et al. [18] | OST&ART | OST | Cost utility | Vietnam health care system | Decision tree monte carlo simulation | 1 year | Infection averted & QALYs |
| Connock et al.[12]** | Buprenorphine | OST (methadone vs buprenorphine) | Cost utility | NHS | Markov monte carlo simulation | 1 year | QALYs |
| Degenhardt et al. [10] | ART, NSP&OST&ART | Combined (NSP&OST) | Cost effectiveness | Transmission model | 5 years | Infection aveted | |
| Alistar, Owens, and Brandeau [19] | OST&ART ART alone | OST | Cost utility | Provider | dynamic compartmental model | 20 year | Infection averted & QALYs |
| Li et al. [20] | ART, VCT | Combined (NSP&OST) | Cost utility | Mathematical | 30 year | Infection averted & QALYs | |
| Van den berg et al.* [21] | Methadone dose or NEP use alone | Combined (NSP& OST) | Not stated | Cohort study | 20 years | Incidence rate ratio | |
| Kwon et al. [22] | no NSP | NSP | Cost utility | Health sector | Mathematical model | lifetime | Infection averted & QALYs |
| Zhang et al. [23] | no NSP | NSP | Cost utility | Societal | Mathematical model | 7 years | Infection averted & DALYs |