Table 6 Sensitivity analysis
Parameter | Baseline value | Sensitivity analysis | New price | ICER | Base case |
|---|---|---|---|---|---|
Sorafenib price | 1816 (per month) | 50% reduction | 908 | 24,190 | 60,000 |
TIME HORIZON | 10 YEARS | 5 YEARS | 1860 | 60,266 | 60,000 |
Discounting | 3.5 | 0 | 2455 | 45,279 | 60,000 |
Discounting | 3.5 | 1.5 | 2124 | 51,025 | 60,000 |
Discounting | 3.5 | 5 | 1695 | 67,203 | 60,000 |
QALY | 0.76 – 0.68 | 0,836 0.748 | 2013 | 54,738 | 60,000 |
QALY | 0.76 – 0.68 | 0.684- 0.612 | 1711 | 66,863 | 60,000 |
Medical and other pharmaceutical costs | Â | Increase 20% | 1926 | 57,407 | 60,000 |
Medical and other pharmaceutical costs | Â | Decrease 20% | 1802 | 62,282 | 60,000 |
Increase of PFS and OS 10% | Â | Â | 2030 | 53,300 | 60,000 |
Increase of OS 10% | Â | Â | 1905 | 58,329 | 60,000 |
Increase of PFS 10% | Â | Â | 1987 | 55,701 | 60,000 |
Decrease of PFS and OS 10% | Â | Â | 1580 | 72,374 | 60,000 |
Decrease of OS 10% | Â | Â | 1790 | 62,695 | 60,000 |
Decrease of PFS 10% | Â | Â | 1655 | 68,853 | 60,000 |