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Table 8 Health outcomes and costs after PHiD-CV vaccination: comparative analysis vs non-vaccination*

From: A cost-effectiveness analysis of a 10-valent pneumococcal conjugate vaccine in children in six Latin American countries

 

Argentina

Brazil

Chile

Colombia

Mexico

Peru

Health outcomes (events averted)

      

Pneumococcal hospitalizations - N(%)

2851 (14.67)

69 415 (15.82)

5709 (15.53)

12 257 (15.69)

6112 (16.55)

6391 (15.70)

Ambulatory pneumonia - N(%)

1292 (1.50)

30 443 (2.05)

4198 (2.03)

2270(1.53)

2887 (2.67)

689 (1.57)

Total pneumonia - N(%)

4143 (3.93)

99 859 (5.18)

9907 (4.06)

14 527 (6.40)

8999 (6.20)

7080 (8.37)

Myringotomies - N(%)

3708 (52.32)

12 532 (34.75)

2461 (47.06)

11 031 (38.34)

9395 (36.82)

2945 (36.48)

AOM sequelae - N(%)

3272 (20.45)

1643 (13.16)

5101 (17.30)

3085 (13.74)

2075 (15.49)

3209 (13.17)

Total AOM - N(%)

67 519 (15.99)

188 353 (10.27)

29180 (15.64)

55 098 (9.72)

75 534 (11.70)

33 323 (9.81)

Pneumococcal meningitis sequelae - N(%)

16 (56.65)

436 (65.46)

32 (48.96)

147 (59.36)

23 (64.87)

11 (37.80)

Pneumococcal meningitis - N(%)

72 (47.32)

876 (45.78)

78 (40.54)

243 (47.44)

70 (42.32)

52 (26.56)

Pneumococcal bacteremia - N(%)

319 (42.34)

3812 (48.08)

107 (45.07)

488 (49.34)

1169 (43.26)

232 (43.89)

Health outcomes (deaths averted)

      

Pneumonoia - N(%)

69 (15.28)

284 (15.40)

16 (15.60)

192 (15.58)

251 (15.92)

199 (15.64)

Pneumococcal meningitis - N(%)

12 (47.32)

282 (51.06

9 (40.85)

36 (52.07)

23 (43.52)

41 (39.29)

Pneumococcal bacteremia - N(%)

14 (48.45)

764 (48.27)

6 (44.09)

50 (51.68)

306 (43.08)

37 (46.78)

Total deaths averted - N(%)

94 (18.77)

1330 (33.43)

31 (22.27)

279 (19.89)

580 (24.80)

240 (17.65)

Life- years gained

      

Pneumonia - N(%)

1829 (15.30)

7379 (15.43)

432 (15.60)

5060 (15.60)

6660 (15.93)

5216 (15.66)

Pneumococcal meningitis - N(%)

310 (47.35)

7335 (51.17)

236 (40.95)

950 (52.13)

610 (43.55)

107 (39.39)

Pneumococcal bacteremia - N(%)

376 (48.50)

19 791 (48.30)

157 (44.11)

1324 (51.73)

8132 (43.10)

982 (46.84)

Total life- years gained - N(%)

2515 (18.79)

34 505 (33.45)

824 (22.28)

7334 (19.92)

15 402 (24.81)

6305 (17.67)

QALYs gained

      

Pneumonia - N(%)

1661 (14.67)

7315 (13.32)

455 (11.43)

4623 (15.20)

6004 (15.72)

4708 (15.54)

AOM - N(%)

8215 (20.27)

4866 (12.60)

12 560 (17.30)

7671 (13.62)

5405 (15.25)

7789 (13.12)

Pneumococcal meningitis - N(%)

406 (47.42)

9336 (49.01)

449 (42.05)

1725 (50.72)

684 (43.23)

190 (36.13)

Pneumococcal bacteremia - N(%)

338 (48.45)

17 706 (48.30)

140 (44.11)

1185 (51.73)

7263 (43.10)

878 (46.83)

Total QALYs gained - N(%)

10658 (19.95)

39 223 (26.28)

13 604 (17.45)

15 204 (16.45)

19 357 (21.02)

13 565 (14.73)

Direct costs (savings)

      

Pneumonia - N(%)

$ 4 033 877 (11)

$ 28 797 257 (13)

$ 4 092 194 (11)

$ 6 596 723 (13)

$ 28 348 389 (14)

$ 1 289 409 (14)

AOM - N(%)

$ 18 167 102 (19)

$ 8 683 587 (14)

$ 20 426 178 (17)

$ 9 909 792 (13)

$ 41 651 823 (14)

$ 2 252 166 (12)

Pneumococcal meningitis - N(%)

$ 229 857 (47)

$ 3 187 488 (45)

$ 319 239 (42)

$ 986 297 (48)

$ 1 902 325 (42)

$ 93 682 (31)

Pneumococcal bacteremia - N(%)

$ 319 575 (42)

$ 1 590 258 (48)

$ 61 749 (45)

$ 531 578 (49)

$ 7 532 168 (43)

$ 58 707 (44)

Total direct costs saving - N(%)

$ 22 750 411 (17)

$ 42 258 590 (14)

$ 24 899 359 (16)

$ 18 024 390 (14)

$ 79 434 704 (15)

$ 3 693 964 (13)

Indirect costs (savings)

      

Pneumonia - N(%)

$ 3 522 333 (13)

$ 22 241 122 (11)

$ 1 400 094 (9)

$ 8 252 215 (14)

$ 8 557 686 (15)

$ 7 451 232 (15)

AOM - N(%)

$ 14 517 543 (20)

$ 9 740 639 (13)

$ 23 286 312 (17)

$ 11 218 127 (14)

$ 6 612 602 (15)

$ 10 446 078 (13)

Pneumococcal meningitis- N(%)

$ 774 859 (47)

$ 19 723 810 (48)

$ 905 497 (41)

$ 2 707 444 (50)

$ 925 147 (43)

$ 287 348 (35)

Pneumococcal bacteremia - N(%)

$ 703 551 (48)

$ 37 630 952 (48)

$ 299 735 (44)

$ 1 966 433 (51)

$ 10 054 366 (43)

$ 1 340 000 (47)

Total indirect costs - N(%)

$ 19 518 286 (19)

$ 89 336 523 (22)

$ 25 891 638 (17)

$ 24 144 218 (16)

$ 26 149 800 (21)

$ 19 524 658 (15)

Cost of vaccination

      

Cost of vaccination

$ 58 299 995

$ 320 297 067

$ 21 768 674

$ 79 164 045

$ 168 367 142

$ 44 052 353

  1. *Analysis is from birth till 10 years of age, discount rate 3.5. All costs are expressed in U$S Dollars. In Brazil, Colombia, Chile and México 2008 local costs were converted to US$ and in Argentina and Perú 2009 local costs were converted to US$ exchange rates are provided in methods.
  2. % from total refers to the percentage of cases attributable to the condition from the total of cases or costs.