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Table 6 Parameters included in sensitivity analysis comparing PHiD-CV vaccination strategy against non- vaccination

From: A cost-effectiveness analysis of a 10-valent pneumococcal conjugate vaccine in children in six Latin American countries

Variable

Base case

Range of sensitivity analysis

Pneumonia – Incidence

Age-specific data

-/+20% for hospitalizations

-/+50% for ambulatory cases

Pneumonia – Case fatality rate

Age-specific data

-/+20%

AOM – Incidence

Age-specific data

-/+20% for myringotomies

-/+50% for total cases

AOM - Etiology

Country-specific data

-/+20% for Sp cases

-/+40% for NTHi cases

AOM – Etiology

Country-specific data

-/+20% for SpC cases

Meningitis – Incidence

Age-specific data

-/+50%

Meningitis – Case fatality rate

Age-specific data

-/+20%

Meningitis – Risk of sequelae

Age-specific data

-/+20%

Bacteremia – Incidence

Age-specific data

-/+50%

Bacteremia – Case fatality rate

Age-specific data

-/+20%

ID - Etiology (Sp serotype distribution)

Age-specific data

95% CI

ID - Etiology (Sp in ≥10 years)

Age-specific data

-/+20%

Effectiveness in reducing hospitalizations for pneumonia

25%

95% CI

Effectiveness in reducing ambulatory pneumonia

4,3%

95% CI

Efficacy in preventing AOM according to type of pathogen (SpC, SpNC y HiNT)

57.6% for SpC

95% CI

-33% for SpNC

35.3% for NTHi

Efficacy in preventing ID

Based on efficacy by serotype for PCV-7

95%CI for each serotype

Costs of administration and vaccine wastage*

1 dollar with 10% wastage

-/+20%

Direct cost of treatment of acute events

Disease-specific data

-/+20%

Annual cost of long term treatment of sequelae

Data specific for each condition

-/+20%

Disutilities associated with AOM (with and without myringotomy)

Data specific for each condition

95% CI

†Disutilities associated with acute diseases except AOM†

Data specific for each condition

95% CI

Disutilities associated with chronic conditions (sequelae)‡

Data specific for each condition

95% CI

  1. ID, Invasive Disease; NTHi, Non typable Haemophilus influenzae: 95% CI: 95% confidence interval; AOM, Acute Otitis Media; Sp, Streptococcus pneumoniae; SpC, Streptococcus pneumoniae serotypes covered by vaccine; SpNC Streptococcus pneumoniae serotypes not covered by vaccine.
  2. †Per episode.
  3. ‡Per year.