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Table 1 Epidemiological input data: acute events

From: A cost-effectiveness analysis of a 10-valent pneumococcal conjugate vaccine in children in six Latin American countries

 

Argentina

Brazil

Chile

Colombia

Mexico

Peru

 

Incidence rate*

CFR† (%)

Incidence rate*

CFR† (%)

Incidence rate*

CFR† (%)

Incidence rate*

CFR† (%)

Incidence rate*

CFR† (%)

Incidence rate*

CFR† (%)

All-cause pneumonia (hospitalized) ‡

            

 0-1 years

1,323.80

3.5

4,026.60

0.8

6,526.20

0.5

2,715.30

3.4

639.8

8.9

2,130.50

7.4

 1-4 years

257.4

1.5

1,562.80

0.2

1,563.20

0.1

1,147.76

0.8

273.31

2

1,034

1.7

 5-9 years

109.9

1

362

0.2

388.6

0

273.3

0.6

31.2

1.6

262.6

1.4

All-cause pneumonia (ambulatory) §

            

 0-1 years

441.3

-

3,643.10

-

15,227.80

-

301.7

-

185.8

-

236.7

-

 1-4 years

922.4

-

4,748.40

-

7,555.30

-

1,265.48

-

956.6

-

646.24

-

5-9 years

1,721.90

-

3,775.10

-

7,384.30

-

2,211

-

281

-

1,050.40

-

All-cause AOM ll

            

 0-1 years

8,943.50

-

6,050.90

-

16,260.20

-

8,943.50

-

4,519.40

-

8,943.50

-

 1-4 years

7,690.50

-

7,563.60

-

10,988.60

-

7,690.55

-

4,519.40

-

7,690.50

-

 5-9 years

4,626.90

-

2,915.30

-

2,882.60

-

4,626.90

-

1,921.90

-

4,626.90

-

Pneumococcal meningitis¶

            

 0-1 years

19.4

16.1

22.5

40

39.4

12.3

28.4

17.5

5.76

40

5.1

20

 1-4 years

0.74

16.1

4.6

25

5.4

10

5.35

13.75

0.61

18.5

1.62

7.5

 5-9 years

0.12

16.1

2.3

10

3.1

10

1.4

4

0.07

5.5

4.9

2

Pneumococcal bacteraemia/sepsis**

            

 0-1 years

54.2

5.5

171.2

22.5

61.5

7.5

61.7

12.5

101.8

30

54.2

20

 1-4 years

9.16

4

8.9

11.3

6.8

2

9.3

7.5

8.94

17.5

8.52

12.5

 5-9 years

4.33

1

2

6.5

1.3

2

2.1

3.5

0.42

5

2.5

2

  1. * per 100,000 people.
  2. †CFR = Case Fatality Ratio.
  3. ‡Pneumonia hospitalization rate and CFR for Brazil and Chile were obtained from national health statistics: Sistema Único de Saúde (SUS) in Brazil [24], National Health System in Chile (División de Planificación Sanitaria. Departamento de Estadísticas e Información de Salud. Ministerio de Salud de Chile, personal communication. April, 2009); The same figures for Mexico were obtained from the social security Instituto Mexicano del Seguro Social (IMSS) [25]. Estimates for Colombia, Peru, and Argentina were derived from mortality rates applying mean CFR for Brazil, Chile and Mexico. In all countries we assumed that all deaths occurred during hospitalization, except Peru, where only 46% of deaths were assumed to occur in the hospital [26].
  4. §Cases of ambulatory pneumonia were estimated in all countries from hospitalization rates based on the proportion of pneumonia requiring hospitalization provided by Delphi panels.
  5. ll Number of cases of AOM for Brazil and Mexico were derived from local studies [27, 28]. Incidence rate for children under 4 years-old was obtained from other local study for Chile [29]., assuming the same age decrement in the incidence rate as described for Brazil Incidence rates for Colombia and Peru were assumed to be the mean rate between Brazil, Chile and Mexico.
  6. ¶ ** The incidence of pneumococcal meningitis and of pneumococcal bacteremia were estimated separately based on the incidence of all-cause IPD and the percentage of cases caused by Spn. Incidence of all-cause IPD for Brazil, Chile and Mexico were obtained from the same sources as pneumonia. Incidence of all-cause IPD for Colombia, Peru and Argentina were derived from mortality rates. Percentage of IPD cases attributable to Spn and CFRs for IPD were derived from Delphi panels for all countries. Delphi panels in Brazil were provided with additional information from local studies.
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Cost Effectiveness and Resource Allocation

ISSN: 1478-7547

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