Table 1 Data inputs used in the model
Mean | SE | Distribution | Source | |
|---|---|---|---|---|
Treatment decision probabilities | ||||
MT, FFR | 0.23 | 0.03 | Dirichlet | FAMOUS |
PCI, FFR | 0.71 | 0.02 | Dirichlet | FAMOUS |
CABG, FFR | 0.06 | 0.02 | Dirichlet | FAMOUS |
MT, standard care | 0.13 | 0.02 | Dirichlet | FAMOUS |
PCI, standard care | 0.80 | 0.01 | Dirichlet | FAMOUS |
CABG, standard care | 0.07 | 0.02 | Dirichlet | FAMOUS |
Equipment costs (£): | ||||
Guiding catheter | 20 | 0 | – | National procurement |
Guidewire | 20 | 0 | – | National procurement |
Pressure wire | 270 | 0 | – | National procurement |
Adenosine vial | 12 | 0 | – | BNF |
Balloon catheter | 50 | 0 | – | National procurement |
Drug eluting stent | 290 | 0 | – | National procurement |
Bare metal stent | 90 | 0 | – | National procurement |
Tirofiban (avg/patient) | 242 | 69 | Gamma | BNF; evidence.nhs.uk |
Bivalirudin (avg/patient) | 625 | 48 | Gamma | BNF; evidence.nhs.uk |
Clopidogrel (per month) | 2 | – | BNF; evidence.nhs.uk | |
Procedure costs (£): | ||||
CABG | 5041 | 313 | Gamma | NHS reference costs |
Echocardiogram | 128 | 26 | Gamma | Golden Jubilee National Hospital |
Optical coherence tomography | 1020 | 204 | Gamma | Golden Jubilee National Hospital |
Intravascular ultrasound | 540 | 108 | Gamma | Golden Jubilee National Hospital |
Chest x-ray | 18 | 4 | Gamma | Golden Jubilee National Hospital |
Hospitalisation costs (£): | ||||
Cath lab time (per hour) | 1681 | 301 | Gamma | ISD Scotland |
Day in CCU | 1492 | 60 | Gamma | Golden Jubilee National Hospital |
Day in ITU | 2288 | 458 | Gamma | Golden Jubilee National Hospital |
Day in general ward | 303 | 17 | Gamma | NHS reference costs |
Inhospital event costs (£): | ||||
Severe bleeding | 222 | 3 | Gamma | NHS reference costs |
Stroke | 2709 | 129 | Gamma | NHS reference costs |
MI | 1492 | 76 | Gamma | NHS reference costs |
Event costs (£): | ||||
Rehospitalisation | 2261 | 452 | Gamma | NICE CG94 |
Revascularisation | 2477 | 63 | Gamma | NHS reference costs |
MI | 2261 | 452 | Gamma | NICE CG94 |
Disease related costs (index year) (£): | ||||
Index year after additional MI | 3228 | 215 | Gamma | NICE CG94 |
Index year of stroke | 16,926 | 428 | Gamma | NICE CG68 |
Additional life-expectancies (years) | ||||
MACE | 10.70 | 2.20 | Normal | Kent et al., NICE CG94 |
No MACE | 5.96 | 1.30 | Normal | Kent et al., NICE CG94 |
Other long-term parameters | ||||
Annual cost post year 1 (£) | 423 | 55 | Gamma | Kent et al., NHS reference costs |
MACE utility change | −0.05 | 0.04 | Beta | Kent et al., Palmer et al. |