Generalized cost-effectiveness analysis of a package of interventions to reduce cardiovascular disease in Buenos Aires, Argentina

Table 2 Relative risks of proposed interventions

Interventions	RR (point estimate used in the model)	Reference source
Population-based
Health education through Mass Media	0.98 (1)	[17]
Reduction of salt in bread through voluntary agreement	0.99 (2)	[16]
Individual (clinical)
Pharmacological Treatment of High Blood Pressure	0.82	[37]
Pharmacological Treatment of High Cholesterol	0.95	[19]
Tobacco cessation therapy with bupropion	0.8	[21]
Combined therapy for patients with> 5% global risk	0.12 (3)	[23]
Combined therapy to > 10% global risk
Combined therapy to > 20% global risk

(1) The translation of reduction in mmHg and cholesterol mg reported by the intervention to relative risk was done using Framingham Risk Equations from Wilson et al, Circulation 1998 [24].
(2) Average population bread consumption was estimated from the Agricultural and Food Secretariat. The average amount of salt in bread was obtained from a survey from the National Institute of Industrial Technology (INTI 2005). Then, we applied the same equation as in (1) to transform mmHg decreases in relative risk reduction
(3) We subtracted the folic acid effect from the polypill paper due to its lack of consistent evidence of efficacy
Population health effects due to the interventions were modeled simulating population specific for age and sex with the observed baseline values of cardiovascular risk and the observed distribution of risk factors drawn from local data [4, 5]

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