Table 2 Frequency of microvascular and macrovascular complications by treatment
Complication | Metformin (/100 pt) | Combination (/100 pt) | Improvement | |
|---|---|---|---|---|
| Â | Â | Â | Absolute | Relative (%) |
Nephropathy | Â | Â | Â | Â |
Microalbuminuria | 21.1 | 18.1 | 3.0 | 14.2 |
Gross proteinuria | 18.8 | 13.4 | 5.4 | 28.7 |
End stage renal disease | 5.9 | 4.4 | 1.5 | 25.4 |
Retinopathy | Â | Â | Â | Â |
Background retinopathy | 30.7 | 23.7 | 7.0 | 22.7 |
Macular edema: | Â | Â | Â | Â |
Detected | 25.4 | 20.6 | 4.7 | 18.7 |
Photocoagulated | 24.3 | 19.9 | 4.5 | 18.4 |
Proliferative retinopathy: | Â | Â | Â | Â |
detected | 12.3 | 7.9 | 4.5 | 36.3 |
photocoagulated | 12.1 | 7.7 | 4.4 | 36.3 |
Blindness | 9.4 | 8.0 | 1.4 | 14.9 |
Neuropathy | Â | Â | Â | Â |
Foot ulcer | 21.1 | 16.3 | 4.8 | 22.7 |
Neuropathy | 12.7 | 9.6 | 3.2 | 24.8 |
1st Lower-extremity amputation | 9.0 | 7.5 | 1.5 | 16.5 |
2nd Lower-extremity amputation | 5.1 | 4.3 | 0.7 | 14.6 |
Macrovascular Disease | Â | Â | Â | Â |
Myocardial infarction | 15.0 | 14.6 | 0.4 | 2.4 |
Stroke | 13.7 | 13.4 | 0.3 | 1.9 |