| 3-month baseline rate | Sources |
---|---|---|
Ischemic stroke | Â | Â |
VKA | 0.40% | ROCKET AF [15] § |
Myocardial infarction | Â | Â |
VKA | 0.28% | ROCKET AF [15] § |
Systemic embolism | Â | Â |
VKA | 0.05% | ROCKET AF [15] § |
Intracranial bleeding | Â | Â |
VKA | 0.19% | ROCKET AF [15] § |
Minor extracranial bleeding | Â | Â |
VKA | 2.97% | ROCKET AF [15] § |
Major extracranial bleeding | Â | Â |
VKA | 0.69% | ROCKET AF [15] § |
 | RR (95% CI) | Sources |
Ischemic stroke | Â | Â |
Rivaroxaban vs. VKA (SOT) | 0.94 (0.75 – 1.17) | ROCKET AF [18] |
Rivaroxaban vs. VKA (ITT) | 0.99 (0.82 – 1.20) | ROCKET AF [15] |
Myocardial infarction | Â | Â |
Rivaroxaban vs. VKA (SOT) | 0.81 (0.63 – 1.06) | ROCKET AF [15] |
Rivaroxaban vs. VKA (ITT) | 0.91 (0.72 – 1.16) | ROCKET AF [15] |
Systemic embolism | Â | Â |
Rivaroxaban vs. VKA (SOT) | 0.23 (0.09 – 0.61) | ROCKET AF [18] |
Rivaroxaban vs. VKA (ITT) | 0.74 (0.42 – 1.32) | ROCKET AF [15] |
Intracranial bleeding | Â | Â |
Rivaroxaban vs. VKA | 0.67 (0.47 – 0.93) | ROCKET AF [15] § |
Major extracranial bleeding | Â | Â |
Rivaroxaban vs. VKA | 1.14 (0.98 – 1.33) | ROCKET AF [18] § |
Minor extracranial bleeding | Â | Â |
Rivaroxaban vs. VKA | 1.04 (0.96 – 1.13) | ROCKET AF [15] § |
 | Mortality rates ¶ | Sources |
Stroke related | Â | Â |
Case fatality of major stroke | 12.6% | ROCKET AF [15] |
Case fatality of minor stroke | 0.00% | Assumption |
Post-major stroke mortality rate | 2.60% | Marini et al. 2005 [19] |
Post-minor mortality rate | 0.00% | Assumption |
Bleeding-related | Â | Â |
Case-fatality of major bleed | 1.60% | ROCKET AF [15] |
Case-fatality of minor bleed | 0.00% | Assumption |
Case-fatality of intracranial bleed | 38.80% | ROCKET AF [15] |
Post- major bleed mortality rate | 0.00% | Assumption |
Post- minor bleed mortality rate | 0.00% | Assumption |
Post- Intracranial bleed mortality rate | 2.60% | Assumption (equal to stroke) |
Systemic embolism-related | Â | Â |
Case-fatality of systemic embolism | 0.00% | Eckman 1992 [20] |
MI-related | Â | Â |
Case-fatality rate of myocardial infarction | 9.69% | ROCKET AF [15] |
Post myocardial infarction mortality rate | 2.68% | Hoit et al. 1986 [21] |