Modelling the cost-effectiveness of a new infant vaccine to prevent tuberculosis disease in children in South Africa

Table 2 Cost of vaccination, diagnosis and treatment ^a in 2012 USD: base-case estimates and source

Parameters	Value	Range	References
Cost of BCG vaccination (USD 2012)^b	13.57	13.43 – 14.28	[34–36] and personal communication (Arnot, Hayes)^d
Cost of MVA85A vaccination (USD 2012)^c	28.22	20.22 – 48.22	[34–36] and personal communication (Oxford Emergent Tuberculosis Consortium (OETC))
Costs of diagnosis & treatment PTB (USD 2012)			[34–36]
0-2 years	406.13		[34–36] and personal communication (Arnot, Hayes, von Zeil)^d
3-5 years	433.13
6-10 years	459.29
Costs of diagnosis & treatment mTB (USD 2012)
0-2 years	3,184.76
3-5 years	3,213.57
6-10 years	3,241.54
Costs of diagnosis & treatment TBM (USD 2012)
0-2 years	29,782.98
3-5 years	29,844.60
6-10 years	29,881.88

^aTB treatment costs: an average weight of 10kg was used for the age group 0-2 years, 20kg for 3-5 years, and 30kg for 6-10 years. As per the South African TB guidelines treatment is given daily (7 days a week) for 6 months (2 months intensive phase and 4 months continuation phase) for pulmonary TB and miliary TB; whereas treatment is given daily for 6-9 months (single phase of treatment) for TB meningitis. Other costs include costs associated with various diagnostics and laboratory monitoring as well as hospital and clinic costs.
^bThe cost of BCG vaccine includes the cost per dose, which includes 40% wastage, the cost for a needle and syringe, and the cost of a clinic visit.
^cThe cost of MVA85A vaccine includes the cost per dose (provided by OETC), the cost for a needle and syringe, and the cost of a clinic visit.
^dProvided information on South African tender award for TB medicines and BCG vaccine as well as wastage rates for BCG vaccine.

ISSN: 1478-7547